The organization, function and maintenance of the genome are the focus of a large number of BMCB laboratories, which form a vibrant community of both established and younger faculty. Students in the BMCB program may choose from a diverse range of laboratories studying topics ranging from DNA repair and DNA replication, to chromatin, nuclear architecture and transcription. A distinct feature of the program is the use of various model organisms and the integration of classical and modern techniques to address fundamental questions in nuclear biology and their implications for human health.