David B. Stern
Professor of Genetics
Scientist, President, Boyce Thompson Institute of Plant Research

David B. Stern

Phone

607-254-1306

Address

Boyce Thompson Institute for Plant Research
301 Boyce Thompson Institute
533 Tower Road
Ithaca, NY 14853-1801

Email

Web Sites

Department Profile

Research Description

The underlying research theme in the Stern laboratory is nuclear-cytoplasmic interactions. Within this framework, we study how chloroplast genes and metabolic activities are regulated by the products of nuclear genes, usually acting at the transcriptional or post-transcriptional level. Chloroplasts, as the site of photosynthesis as well as other metabolic pathways, have numerous roles in plant development, and responses to environmental stimuli. Our laboratory focuses on how these roles are modulated through intensive studies of global and individual gene regulation under normal growth or stress conditions. We use different techniques including genetics, plant transformation, and biochemistry to unravel these processes.

Publications

Bohne, A. V., V. Ihrimovitch, A. Weihe, D. B. Stern. 2006. Chlamydomonas reinhardtii Encodes a Single sigma70-like Factor Which Likely Functions in Chloroplast Transcription. Current Genetics 49: 333-340.

Rymarquis, L. A., D. C. Higgs, D. B. Stern. 2006. Nuclear Suppressors Define Three Factors that Participate in Both 5’ and 3’ End Processing of mRNAs in Chlamydomonas chloroplasts. The Plant Journal 46: 448-461.

Cui, L., J. Leebens-Mack, L. S. Wang, J. Tang, L. Rymarquis, D. B. Stern, C. W. dePamphilis. 2006. Adaptive Evolution of Chloroplast Genome Structure Inferred Using a Parametric Bootstrap Approach. BMC Evolutionary Biology 6: 13.

Irihimovitch, V., D. B. Stern. 2006. The sulfur acclimation SAC3 kinase is required for chloroplast transcriptional repression under sulfur limitation in Chlamydomonas reinhardtii. Proc Natl Acad Sci USA 103: 7911-7916.

Bollenbach, T. J., H. Lange, R. Gutierrez, D. B. Stern, D. Gagliardi. 2005. RNR1, a 3’-5’ Exoribonuclease Belonging to the RNR Superfamily, Catalyzes 3’ Maturation of Chloroplast Ribosomal RNAs in Arabidopsis thaliana. Nucleic Acids Research 33: 2751-2763.

Rymarquis, L. A., J. M. Handley, M. Thomas, D. B. Stern. 2005. Beyond Complementation: Map-Based Cloning in Chlamydomonas reinhardtii. Plant Physiology 137: 557-566.

Erickson, B., D. B. Stern, D. C. Higgs. 2005. Microarray Analysis Confirms the Specificity of a Chlamydomonas reinhardtii Chloroplast RNA Stability Mutant. Plant Physiology 137: 534-544.

Murakami, S., K. Kuehnle, D. B. Stern. 2005. A Spontaneous tRNA Suppressor of a Mutation in the Chlamydomonas reinhardtii Nuclear MCD1 Gene Required for Stability of the Chloroplast petD mRNA. Nucleic Acids Research 33: 3372-3380.

Cohen, I., J. A. Knopf, V. Irihimovitch, M. Shapira. 2005. A Proposed Mechanism for the Inhibitory Effects of Oxidative Stress on Rubisco Assembly and Its Subunit Expression. Plant Physiology 137: 738-746.

Stern, D. B., M. R. Hanson, A. Barkan. 2004. Genetics and Genomics of Chloroplast Biogenesis: Maize as a Model System. Trends in Plant Science 9: 293-301.

Nishimura, Y., E. A. Kikis, S. L. Zimmer, Y. Komine, D. B. Stern. 2004. Antisense Transcript and RNA Processing Alterations Suppress Instability of Polyadenylated mRNA in Chlamydomonas chloroplasts. Plant Cell 16: 2849-2869.

All publications