Paul Soloway
Professor

Paul D. Soloway

Phone

607-254-6444

Address

Division of Nutrition
211 Weill Hall
Cornell University
Ithaca, NY 14853-2703

Email

Web Sites

Department Profile

Lab Web Site

Background

Formal education includes a B.A. 1979 from Cornell University in Biology and a Ph.D. 1989 from Princeton University in Molecular Biology. Postdoctoral training was at MIT and the Whitehead Institute from 1998-1994. Independent positions as a Principal Investigator were at Roswell Park Cancer Institute from 1994-2002 and at Cornell University from 2002 to the present. Area of expertise is mouse molecular genetics, mechanisms controlling placement of epigenetic modifications including DNA and histone methylation in the mouse genome and technology development for genome wide epigenetic profiling.

Research Description

Current research activities are in the area of epigenetics and includes several separate sets of projects. One of these seeks to characterize the mechanisms regulating the epigenetic phenomena of DNA and histone methylation in mice using the Rasgrf1 gene as a model. These methylation events are potent regulators of gene expression and respond to environmental variables, including nutritional variables, in ways that are stable and inheritable. A second set of projects seeks to identify how different histone and DNA methylation events are coordinated, either positively or negatively in the genome. A third set of projects is being conducted in collaboration with Harold Craighead. The goal is to develop and utilize single molecule profiling of multiple epigenetic states, simultaneously and genome wide using a nanofluidic device.

Publications

Watanabe, T., Tomizawa, S., Mitsuya, K., Totoki, Y., Yamamoto, Y., Kuramochi-Miyagawa, S., Iida, N., Hoki, Y., Murphy, P. J., Toyoda, A., Gotoh, K., Hiura, H., Arima, T., Fujiyama, A., Sado, T., Shibata, T., Nakano, T., Lin, H., Ichiyanagi, K., Soloway, P. D., and Sasaki, H. (2011) Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Science 332, 848-852.

Wang, X., Soloway, P. D., and Clark, A. G. (2011) A Survey for Novel Imprinted Genes in the Mouse Placenta by mRNA-seq. Genetics 189, 109-122.

Flax, J. D., and Soloway, P. D. (2011) Methylation on the mind. Nat Neurosci 14, 1494-1496.

Drake, N. M., Devito, L. M., Cleland, T. A., and Soloway, P. D. (2011) Imprinted Rasgrf1 expression in neonatal mice affects olfactory learning and memory. Genes Brain Behav 10, 392-403.

Wang, X., Soloway, P. D., and Clark, A. G. (2010) Paternally biased X inactivation in mouse neonatal brain. Genome Biol 11, R79.

Cipriany, B. R., Zhao, R., Murphy, P. J., Levy, S. L., Tan, C. P., Craighead, H. G., and Soloway, P. D. (2010) Single Molecule Epigenetic Analysis in a Nanofluidic Channel. Anal Chem 82, 2480–2487.

Brideau, C. M., Kauppinen, K. P., Holmes, R., and Soloway, P. D. (2010) A Non-Coding RNA Within the Rasgrf1 Locus in Mouse Is Imprinted and Regulated by Its Homologous Chromosome in Trans. PLoS ONE 5, e13784.

Brideau, C. M., Eilertson, K. E., Hagarman, J. A., Bustamante, C. D., and Soloway, P. D. (2010) Successful Computational Prediction of Novel Imprinted Genes From Epigenomic Features. Mol Cell Biol 30, 3357–3370.

Drake, N. M., Park, Y. J., Shirali, A. S., Cleland, T. A., and Soloway, P. D. (2009) Imprint switch mutations at Rasgrf1 support conflict hypothesis of imprinting and define a growth control mechanism upstream of IGF1. Mamm Genome 20, 654-663.

Wang, X., Sun, Q., McGrath, S. D., Mardis, E. R., Soloway, P. D., and Clark, A. G. (2008) Transcriptome-wide identification of novel imprinted genes in neonatal mouse brain. PLoS ONE 3, e3839.

Lindroth, A. M., Park, Y. J., McLean, C. M., Dokshin, G. A., Persson, J. M., Herman, H., Pasini, D., Miro, X., Donohoe, M. E., Lee, J. T., Helin, K., and Soloway, P. D. (2008) Antagonism between DNA and H3K27 Methylation at the Imprinted Rasgrf1 Locus. PLoS Genetics 4, e1000145.

Soloway, P. D. (2006) Gene nutrient interactions and evolution. Nutr Rev 64, S52-54; discussion S72-91.

Soloway, P. D. (2006) Paramutable Possibilities. Nature 441, 413-414.

Holmes, R., and Soloway, P. D. (2006) Regulation of imprinted DNA methylation. Cytogenet Genome Res 113, 122-129.

Holmes, R., Chang, Y., and Soloway, P. D. (2006) Timing and Sequence Requirements Defined for Embryonic Maintenance of Imprinted DNA Methylation at Rasgrf1. Mol Cell Biol 26, 9564-9570.

Yoon, B.-J., Herman, H., Hu, B., Park, Y. J., Lindroth, A. M., Bell, A., West, A. G., Chang, Y., Stablewski, A., Piel, J. C., Loukinov, D. I., Lobanenkov, V., and Soloway, P. D. (2005) Rasgrf1 Imprinting is Regulated by a CTCF-dependent Methylation-Sensitive Enhancer Blocker. Mol Cell Biol 25, 11184–11190.

Lee, M. M., Yoon, B. J., Osiewicz, K., Preston, M., Bundy, B., van Heeckeren, A. M., Werb, Z., and Soloway, P. D. (2005) Tissue inhibitor of metalloproteinase 1 regulates resistance to infection. Infect Immun 73, 661-665.

Herman, H., Lu, M., Anggraini, M., Sikora, A., Chang, Y., Yoon, B. J., and Soloway, P. D. (2003) Trans allele methylation and paramutation-like effects in mice. Nat Genet 34, 199-202.

Yoon, B. J., Herman, H., Sikora, A., Smith, L. T., Plass, C., and Soloway, P. D. (2002) Regulation of DNA methylation of Rasgrf1. Nat Genet 30, 92-96.

Fitzpatrick, G. V., Soloway, P. D., and Higgins, M. J. (2002) Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1. Nat Genet 32, 426 - 431.

Wang, Z., Juttermann, R., and Soloway, P. D. (2000) TIMP-2 is required for efficient activation of proMMP-2 in vivo. J Biol Chem 275, 26411-26415.