Sondra G. Lazarowitz
Professor

Sondra Lazarowitz

Phone

607-255-7830

Address

Department of Plant Pathology
Cornell University
Ithaca, NY 14853-2703

Email

Web Sites

Department Profile

Lab Web Site

Background

Ph. D. Rockefeller University, 1975
S.B. Massachusetts Institute of Technology, 1970

 

2001-Present Director, Howard Hughes Undergraduate Program, Cornell University
1998 - Present Professor, Department of Plant Pathology, Cornell University
2001 Symposium Speaker, 10th International Congress on Molecular Plant-Microbe Interactions
1999 Symposium Speaker, American Society for Virology Annual Meeting
1998 National Science Foundation Career Advancement Award
1995 Keynote Speaker, McKnight Symposium, North Carolina State University

Research Description

Our long term goals are to understand the mechanisms that regulate intracellular and intercellular trafficking in plants, and common plant cell responses to pathogen attack. Most of our efforts focus on the biochemical functions and cellular interactions of the two movement proteins NSP and MP encoded by the bipartite geminiviruses, using these as models to investigate nuclear shuttling and the biogenesis of channels in plant cell walls. In collaboration with Alan Collmerís lab, we are also taking a functional genomics approach to investigate the roles of bacterial avirulence (avr) proteins in pathogenesis and in inducing host resistance responses in plants. The model geminiviruses we employ are SqLCV (squash leaf curl virus), which has a broad host range in cucurbits, and the closely-related CLCV (cabbage leaf curl virus), which has a broad host range in Brassica that includes Arabidopsis. Our functional genomics studies employ the model plant pathogenic bacterium Pseudomonas syringae pv. tomato DC3000.

Publications

Carvalho, M. F., and S. G. Lazarowitz. 2004. Interaction of the geminivirus movement protein NSP and the Arabidopsis acetyltransferase AtNSI is necessary for virus infection and pathogenicity. J Virol: 78: 11161-11171.

Lazarowitz, S. G., R. C. McGarry, Y. D. Barron, and M. F. Carvalho. 2004. Nuclear shuttling in plant cells. In The Nuclear Envelope. D. A. Evans, J. Bryant and C. Hutchison (ed.), SEB. BIOS Scientific Publishers, Abingdon. pp. 157-176.

Click here for Dr. Lazarotwitz's PubMed listings.