Jan Lammerding
Assistant Professor

Phone

607-255-1700

Address

Department of Biomolecular Engineering
Cornell University
235 Weill Hall
Ithaca, NY 14853

Email

Web Sites

Department Profile

Lab Website

Background

Jan Lammerding joined Cornell University in 2011 after six years on the faculty in the Department of Medicine at Harvard Medical School/Brigham and Women's Hospital, where he received the Department of Medicine Young Investigator Award, the Cardiovascular Leadership Group Award, and the Lerner Young Investigator Award. During that time, he also served three years as lecturer in the Department of Biological Engineering at the Massachusetts Institute of Technology (MIT). Dr. Lammerding completed a postdoctoral fellowship at Brigham and Women's Hospital in the Cardiovascular Division. Originally from Germany, Dr. Lammerding studied mechanical engineering at the University of Technology (RWTH) Aachen, encompassing a fellowship to study at the Thayer School of Engineering at Dartmouth College, before moving to the U.S. to enroll in the newly founded Ph.D. program in Biological Engineering at MIT.

Research Description

The research in my group is focused on developing and applying novel experimental techniques to explore the interplay between cellular structure and function, with a particular emphasis on the cell nucleus and the nuclear envelope. Recent discoveries provide compelling evidence that the physical properties of the nucleus are critical for a multitude of cellular functions, and that defects in nuclear structure and organization can contribute to a large number of human diseases, ranging from muscular dystrophies and cardiomyopathies to premature aging and cancer. While many of the projects in our laboratory are aimed at elucidating the molecular mechanisms underlying human diseases caused by mutations in nuclear envelope proteins, our research will also provide important insights into the normal functions of these proteins.

Selected Publications

Jaalouk, D.E., and J. Lammerding (2009) "Mechanotransduction gone awry." Nature Reviews Molec. Cell Biol. 10 (1): 63-73.

Friedl, P., K. Wolf, and J. Lammerding (2011) "Nuclear mechanics during cell migration." Curr. Opin. Cell Biol. 23 (1): 55-64.

Ho, C.Y. and J. Lammerding (2012) "Lamins at a glance.” J. Cell. Sci. 125 (9) 2087-2093.

Zwerger, M., D. Jaalouk, M. Lombardi, P. Isermann, M. Mauermann, G. Dialynas, H. Hermann, L. Wallrath, and J. Lammerding (2013) "Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleocytoskeletal coupling." Hum. Molec. Genetics 22 (12): 2335-2349.

Rowat, A., D.J. Jaalouk, M. Zwerger, W.L. Ung, I.A. Eydelnant, D. Olins, A. Olins, H. Herrmann, D.A. Weitz, and J. Lammerding (2013) "Nuclear envelope composition determines the ability of neutrophil-type cells to passage through micron-scale constrictions." J. Biol. Chem. 288 (12): 8610-8618.