Gunther Hollopeter
Assistant Professor

Gunther Hollopeter

Phone

607-253-3604

Address

Department of Molecular Medicine
Cornell University
C3 171 Veterinary Medical Center
Ithaca, NY 14853

Email

Web Sites

Department Profile
Lab Website

Background

Gunther Hollopeter received a BS in Cell and Molecular Biology in 1996 from the University of Washington-Seattle and a Ph.D. in Neuroscience in 2005 from the University of California, San Francisco.   From 2006-2011, he was a Postdoctoral Fellow at the University of Utah under the guidance of Prof. Erik Jorgensen, and from 2011-2015 he was a Visiting Scholar at Stowers Institute, Kansas City.  In September 2015, he was appointed as an Assistant Professor in the Department of Molecular Medicine at Cornell University.

Research Description

My laboratory elucidates mechanisms by which cellular machines regulate membrane trafficking. We employ a multidisciplinary approach by combining genetic screens, live imaging and biochemistry in C. elegans, with proteomics and structural biology. The foundations of this program were laid during my postdoctoral fellowship at the University of Utah and Stowers Institute for Medical Research where I discovered that a conserved class of membrane-associated proteins initiate endocytosis by converting the AP2 clathrin adaptor complex to an active conformation. Currently, we are working out how another class of highly conserved proteins are acting as negative regulators of the endocytic machinery. Ongoing projects in the lab are focused on identifying additional regulators of endocytosis and will determine their function at the molecular, cellular and organismal levels. Additional goals of the lab are to expand our repertoire of structural biology approaches and to screen for pharmacological activators of the trafficking machinery for use in other systems and disease models

Selected Publications

Hollopeter G, Lange JJ, Zhang Y, Vu TV, Gu M, Ailion M, Lambie EJ, Slaughter BD, Unruh JR, Florens L, Jorgensen EM.  The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex (2014). eLife 10.7554/eLife.03648.

Liu Q, Hollopeter G, Jorgensen EM.  Graded synaptic transmission at the Caenorhabditis elegans neuromuscular junction (2009). Proc. Natl. Acad. Sci. 106:10823-8.

Hollopeter G, Jantzen HM, Vincent D, Li G, England L, Ramakrishnan V, Yang RB, Nurden P, Nurden A, Julius D, Conley PB.  Identification of the platelet ADP receptor targeted by antithrombotic drugs (2001). Nature 409: 202-207.

Erickson JC, Hollopeter G, Palmiter RD.  Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y (1996). Science 274:1704-1707.