Susan Henry
Professor of Molecular Biology and Genetics
Ronald P. Lynch Dean of the College of Agriculture and Life Sciences

Susan Henry

Phone

607-254-8717

Address

Department of Molecular Biology & Genetics
249 Biotechnology Building
Cornell University
Ithaca, NY 14853-2703

Email

Web Sites

Lab Web Site
Department Profile

Background

Susan Henry is the Ronald P. Lynch Dean of the College of Agriculture and Life Sciences, and Professor of Molecular Biology and Genetics. Dr. Henry received her B.S. degree in Zoology from the University of Maryland and her Ph.D. degree in Genetics from the University of California at Berkeley.  She is a Fellow of the American Association for the Advancement of Science, and a Fellow of the American Academy of Microbiology.   Dr. Henry's research is supported by a grant from the NIH.

Research Description

The research in Susan Henry’s laboratory focuses on regulation of membrane lipid metabolism in yeast and its coordination with membrane trafficking and signal transduction (Gaspar et al., 2006b; Jesch and Henry, 2005; Nunez and Henry, 2005). Most recently, we have shown that signals arising from lipid metabolism in the endoplasmic reticulum (ER) influence major transcriptional networks in the cell (Gaspar et al., 2006a; Jesch et al., 2006; Jesch et al., 2005; Loewen et al., 2004). This metabolism influences, and is influenced by, several major signal transduction pathways including the unfolded protein response pathway (Chang et al., 2004; Chang et al., 2002) and the protein-kinase (PKC) pathway (Sreenivas et al., 2001 Nunez, 2006;) and the glucose response pathway (Shirra et al., 2001). more

Publications

Nunez, L. 2006. Phospholipid biosynthesis in yeast: The role of the PKC1-MPK1 signal transduction pathway, Ph.D. Thesis, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY.

M. L. Gaspar, M. A. Aregullin, S. A. Jesch, L. R. Nunez, M. Villa-Garcia, and S. A. Henry. 2006b. The emergence of yeast lipidomics. In: Regulation of Lipid Metabolism in Yeast, G. Carman and S. A. Henry (Ed.). Biochimica et Biophysica Acta, in press.

S. A. Jesch, P. Liu, X. Zhao, M. T. Wells, and S. A. Henry. 2006. Multiple endoplasmic reticulum-to-nucleus signaling pathways coordinate phospholipid metabolism with gene expression by distinct mechanisms. J. Biol. Chem., 281: 24070-24083.

M. L. Gaspar, M. A. Aregullin, S. A. Jesch, and S. A. Henry. 2006a. Inositol Induces a Profound Alteration in the Pattern and Rate of Synthesis and Turnover of Membrane Lipids in Saccharomyces cerevisiae. J. Biol. Chem., 281: 22773-22785.

H. A. Boumann, J. Gubbens, M. C. Koorengevel, C. S. Oh, C. E. Martin, A. J. Heck, J. Patton-Vogt, S. A. Henry, B. de Kruijff, and A. I. de Kroon. 2006. Depletion of Phosphatidylcholine in Yeast Induces Shortening and Increased Saturation of the Lipid Acyl Chains: Evidence for Regulation of Intrinsic Membrane Curvature in a Eukaryote. Mol Biol Cell, 17:1006-1017.

S. A. Jesch and S. A. Henry. 2005. Yeast Inositol Lipids: Synthesis, Regulation, and Involvement in Membrane Trafficking and Lipid Signaling. In: Cell Biology and Dynamics of Yeast Lipids, G. Daum (Ed.). Research Signpost, Kerala, India, Vol: 37/661: 105-131.

L. R. Nunez and S. A. Henry. 2005. Regulation of 1D-myo-inositol-3-phosphate Synthase in Yeast. In: Subcellular Biochemistry: Biology of Inositols and Phosphoinositides, Ed. A. L. Majumder and B. B. Biswas, Kluwer Academic/Plenum Publishers, London, UK, Vol. 39: 135-156.

S. A. Jesch, X. Zhao, M. T. Wells, and S. A. Henry. 2005. Genome Wide Analysis Reveals Inositol, Not Choline, as the Major Effector of Ino2p-Ino4p and Unfolded Protein Response Target Gene Expression in Yeast. J. Biol. Chem., 280: 9106-9118.

Click here to view Dr. Henry's PubMed listings.