Andrew Grimson
Assistant Professor of Molecular Biology & Genetics

Andrew Grimson

Phone

607-254-1307

Address

Department of Molecular Biology and Genetics
455 Biotechnology Building
Cornell University
Ithaca, NY 14853-2703

Email

Web Sites

Department Profile

Background

Andrew Grimson is an Assistant Professor in the Department of Molecular biology & Genetics. He received a B.A. in Genetics at Trinity College Dublin(Ireland) in 1997, and a Ph.D. in Genetics at the University of Wisconsin-Madison in 2004. As a graduate student he worked on the genetics and the biochemistry of nonsense-mediated mRNA decay, a eukaryotic mRNA decay pathway. In 2004, he joined the Bartel laboratory at the Whitehead Institute for Biomedical Research as a National Institutes of Health Postdoctoral fellow. His postdoctoral research focused on microRNA-mediated (miRNA) regulation of target mRNAs and the early evolution of miRNAs in animals. He joined the Cornell faculty in 2009.

Research Description

The Grimson lab focuses on post-transcriptional gene regulation, in particular the identity and function of animal microRNAs and other small RNAs, as well as explorations into novel regulatory functions encoded in the 3' untranslated region (3'UTR)..  To address these research areas, we use a combination of approaches, including molecular biology, high-throughput genome-scale datasets (e.g., high-throughput sequencing, microarrays), and computational biology/bioinformatics analysis. more

Publications

Grimson, A., Farh, K.K., Johnston, W.K., Garrett-Engele, P., Lim, L.P. and Bartel, D.P. (2007). MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol. Cell 27, 91-105. 

Grimson, A., Srivastava, M., Fahey, B., Woodcroft, B.J., Chiang, H.R., King, N., Degnan, B.M., Rokhsar, D.S. and Bartel, D.P. (2008) Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals. Nature 455, 1193-1197.

Merritt, C., Rasoloson, D., Ko, D. and Seydoux, G. (2008)  3' UTRs are the primary regulators of gene expression in the C. elegans germline. Curr. Biol. 18, 1476-1482. 

Sandberg, R., Neilson, J.R., Sarma, A., Sharp, P.A. and Burge, C.B. (2008) Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites. Science 320, 1643-1647.

Xie, X., Lu, J., Kulbokas, E.J., Golub, T.R., Mootha, V., Lindblad-Toh, K., Lander, E.S. and Kellis, M. (2005) Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature. 2005 434, 338-345.