Maria Garcia-Garcia
Assistant Professor

Maria Garcia-Garcia

Phone

607-254-4679

Address

Department of Molecular Biology & Genetics
259 Biotechnology Building
Cornell University
Ithaca, NY 14853-2703

Email

Web Sites

Lab Web Site
Department Profile

Background

Maria J Garcia is an Assistant Professor in the Department of Molecular Biology and Genetics. She received a B.S. degree in Biology from Universidad Autonoma de Madrid (Spain) in 1994. In 1999, she received a Ph.D. in Biochemistry and Molecular Biology at CBM Severo Ochoa (Madrid. Spain) for her studies on the patterning of the sensory system of the fruitfly Drosophila melanogaster. She then joined Dr. Kathryn V. Anderson at Sloan-Kettering Institute (New York) as a postdoctoral fellow, where she worked on the identification and characterization of mouse ENU mutants affecting early embryogenesis. 

Research Description

Our laboratory is interested in understanding how cellular movements are regulated during development and how they contribute to generate the shape of embryonic tissues and ultimately the adult animal. We use mouse as a model organism, and forward genetics as our experimental approach to isolate mutations that disrupt cell migration during embryogenesis. We also use fly genetics and cell culture analysis to characterize the functions of the genes that we isolate in the mouse. For more details on our research projects, please visit our lab webpage at: http://www.people.cornell.edu/pages/mjg75/

Publications

Caspary, T., García-García, M.J., Huangfu, D., Eggenschwiler, J.T., Wyler, M.R., Rakeman, A.S., Alcorn, H. and Anderson, K.V. (2002) “Mouse Dispatched homologue1 is required for long-range but not juxtacrine Hh signaling” Curr. Biol. 17, 1628-1632.

García-García, M.J. and Anderson, K.V. (2003) “Essential role of glycosaminoglycans for Fgf signaling during mouse gastrulation” Cell 114, 727-737.

Merrill, B.J., Passoli, H.A., Polak, L., Rendl, M., García-García, M.J., Anderson, K.V. and Fuchs, E. (2004) “Tcf3: a transcriptional regulator of axis induction in the early embryo” Development 131 (2), 263-274.

García-García, M.J. , Eggenschwiler, J.T., Caspary, T., Alcorn, H.L., Wyler, M.R., Huangfu, D., Rakeman, A.S., Lee, J.D., Feinberg, E.H., Timmer, J.R. and Anderson, K.V. (2005) "Analysis of mouse embryonic patterning and morphogenesis by forward genetics" Proc. Natl. Acad. Sci. USA 102(17), 5913-5919.

García-García, M.J., Shibata, M. and Anderson, K.V. (2008) "Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo" Development 135(18), 3053-62.