Steven E.  Ealick
William T. Miller Professor and Director of NE-CAT

Phone

607-255-7961

Address

Department of Chemistry and Chemical Biology
382A Spencer T. Olin Laboratory
Cornell University
Ithaca, NY 14853-2703

Email

Web Sites

Background

PhD, University of Oklahoma, 1976
BS, Oklahoma State University, 1972

Leukemia Society of America Special Fellow and Scholar Development Award
Office of Naval Research Young Investigator

Research Description

We use X-ray crystallography to study the three-dimensional structures of proteins. The structural information is used for drug design, protein engineering, to understand catalytic mechanisms, and to explore protein evolution. Our group is also involved in the development of tools and techniques associated with synchrotron radiation, especially multiple wavelength anomalous diffraction (MAD). Our main projects include studies of enzymes involved in purine nucleotide metabolism and pyrimidine nucleotide metabolism, studies of enzymes involved in co-factor biosynthesis, especially thiamin biosynthesis, and enzymes involved in polyamine biosynthesis. more

Publications

Jurgenson CT, Burns KE, Begley TP, and Ealick SE. Crystal Structure of a Sulfur Carrier Protein Complex Found in the Cysteine Biosynthetic Pathway of Mycobacterium tuberculosis. Biochemistry 47: 10354-10364 (2008).

Morar M, Hoskins AA, Stubbe J, and Ealick SE. Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima: Structural Insights into Complex Formation. Biochemistry 47:7816-7830 (2008).

McCulloch KM, Kinsland C, Begley TP, and Ealick SE. Structural Studies of Thiamin Monophosphate Kinase in Complex with Substrates and Products. Biochemistry 47: 3810-3821 (2008).

Soriano EV, Rajashankar KR, Hanes JW, Bale S, Begley TP and Ealick SE. Structural Similarities between Thiamin-Binding Protein and Thiaminase-I Suggest a Common Ancestor. Biochemistry 47:1346-1357 (2008).

Zhang Y, White RH and Ealick SE. Crystal Structure and Function of 5-Formaminoimidazole-4-carboxamide-1-b-D-ribofuranosyl 5-Monophosphate Synthetase from Methanocaldococcus jannaschii. Biochemistry 47:205-217 (2008).