Brian R. Crane
Associate Professor

Phone

607-254-8634

Address

Department of Chemistry and Chemical Biology
G-60 Spencer T. Olin Laboratory
Cornell University
Ithaca, NY 14853-2703

Email

Web Sites

Background

PhD, The Scripps Research Institute 1996
BSc, University of Manitoba, Canada, 1990

2005 Alfred P. Sloan Research Foundation Fellow
Searle Scholar
NSF CAREER Award
Camille and Henry Dreyfus Young Faculty Award
Research Innovation Award, Research Corporation
Helen Hay Whitney Postdoctoral Fellow
Skaggs Foundation Research Fellow
1967 Predoctoral Fellow, Natural Sciences and Engineering Research Council of Canada

Research Description

Research in the Crane Group is directed towards understanding interactions among proteins, electrons, and photons. Specifically, we are interested in how metalloenzymes stabilize transient intermediates during catalysis, how protein structure controls long-range electron transfer, and how photo and redox processes are used in biological information transfer. To correlate protein structure directly with reactivity we combine genetic and chemical manipulation of proteins, atomic-resolution structure determination, and novel photochemically triggered experiments in single crystals.  more

Publications

Zoltowski, B.D., Schwerdtfeger, C., Widom, J. Loros, J.J., Bilwes, A. M., Dunlap, J.,C. & Crane, B.R. (2007) Conformational switching in the fungal light sensor Vivid. Science, 316 1054-1057.

Park, S. Y., Borbat, P. P., Gonzalez-Bonet, G., Bhatnagar, J., Freed, J. H., Bilwes, A. M. & Crane, B. R. (2006). Reconstruction of the chemotaxis receptor:kinase assembly Nat. Struct. Mol. Biol., 13, 400-407.

Chao, X., Muff, T., Park, S., Zhang, S., Pollard, A. M., Ordal, G., Bilwes, A. M. & Crane, B.R. (2006). A receptor-modifying deamidase in complex with a signaling phosphatase reveals a mechanism of reciprocal regulation. Cell 124, 561-571.

Kang, S. A. & Crane, B.R. (2005). Effects of interface mutations on association modes and electron transfer rates between proteins. Proc. Natl. Acad. Sci. USA, 102, 15465-15470.

Kers, J. A., Wach, M. J., Krasnoff, S. B., Widom, J., Cameron, K. D., Bukhalid, R. A., Gibson, D. M., Crane, B. R. & Loria, R. (2004). Nitration of a peptide phytotoxin by bacterial nitric oxide synthase. Nature 429, 79-82.

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