Benjamin D. Cosgrove
Assistant Professor
Benjamin D. Cosgrove

Phone

607-255-7271

Address

Department of Biomedical Engineering
159 Weill Hall
Cornell University
Ithaca, NY 14853

Email

Web Sites

Department Profile

Lab Website

Research Description

The Cosgrove research group is broadly interested in understanding how stem cells use the integrative action of their regulatory circuitry to interpret and balance diverse streams of microenvironmental “information.”  We utilize mouse model systems that exhibit aging-related declines in regenerative capacity, including skeletal muscle, liver, and hematopoietic tissues. In particular, we focus on these main areas of investigation:

(1) We engineer biomimetic microenvironments for evaluating stem cell–niche interactions.

(2) We develop single-cell assay and modeling approaches to deconstruct how stem cell fate outcomes are dictated by diverse niche microenvironmental cues. In particular, we focus on elucidating how heterogeneous stem cell fate outcomes emerge from deterministic signaling and regulatory circuits.

(3) We deconvolve the logic-based communication networks of overlapping autocrine and paracrine signals used by stem cells to communicate with their surrounding microenvironment.

These approaches will enable the improvement of rationally designed, quantitatively predictable stem cell-targeted regenerative medicine therapies to treat tissue aging and degeneration.

Selected
Publications

Cosgrove BD, Gilbert PM, Porpiglia E, Mourkioti F, Lee SP, Corbel SY, Llewelly ME, Delp SL, Blau HM (2014) Rejuvenation of the muscle stem cell population restores strength to injured aged muscles.  Nature Medicine 20(3):255-64.

Principles of Regenerative Medicine (2011) Cosgrove BD, Blau HM. 2nd ed. Lanza RP, Atala A, Thomson JA, Nerem RM, editors. London: Academic Press; Chapter 20, Skeletal muscle stem cells; p.347-363.

Alexopoulos LG, Saez-Rodriguez J, Cosgrove BD, Lauffenburger DA, Sorger PK (2010) Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes.  Molecular & Cellular Proteomics 9(9):1849-65.

Cosgrove BD, Alexopoulos LG, Hang TC, Hendriks BS, Sorger PK, Griffith LG, Lauffenburger DA (2010) Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation.  Molecular BioSystems 6(7):1195-206.

Gardner MK, Sprague BL, Pearson CG, Cosgrove BD, Bicek AD, Bloom K, Salmon ED, Odde DJ (2010) Model convolution: a computational approach to digital image interpretation.  Cellular and Molecular Bioengineering 3(2):163-170.

Cosgrove BD, Sacco A, Gilbert PM, Blau HM (2009) A home away from home: challenges and opportunities in engineering in vitro muscle satellite cell niches.  Differentiation; Research in Biological Diversity. 78(2-3):185-94.

Lee JH, Cosgrove BD, Lauffenburger DA, Han J (2009) Microfluidic concentration-enhanced cellular kinase activity assay.  Journal of the American Chemical Society. 131(30):10340-1.

Pritchard JR, Cosgrove BD, Hemann MT, Griffith LG, Wands JR, Lauffenburger DA (2009) Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death.  Molecular Cancer Therapeutics 8(8):2183-92.

Cosgrove BD, King BM, Hasan MA, Alexopoulos LG, Farazi PA, Hendriks BS, Griffith LG, Sorger PK, Tidor B, Xu JJ, Lauffenburger DA (2009) Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.  Toxicology and Applied Pharmacology 237(3):317-30.

Cosgrove BD, Alexopoulos LG, Saez-Rodriguez J, Griffith LG, Lauffenburger DA (2009) A multipathway phosphoproteomic signaling network model of idiosyncratic drug- and  inflammatory cytokine-induced toxicity in human hepatocytes.  Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society 2009:5452-5.

Cosgrove BD, Cheng C, Pritchard JR, Stolz DB, Lauffenburger DA, Griffith LG (2008) An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-alpha. Hepatology 48(1):276-88.

Cosgrove BD, Griffith LG, Lauffenburger DA (2008) Fusing tissue engineering and systems biology toward fulfilling their promise.  Cell Molecular Bioengineering 1(1):33-41.