Ruth Collins
Associate Professor

Ruth Collins

Phone

607-253-4123, 607-253-4120

Address

Department of Molecular Medicine
C4-109 Veterinary Medical Center
College of  Veterinary Medicine
Cornell University
Ithaca, NY 14853-2703

Email

Web Sites

Department Profile

Background

Post-doctoral Fellow, Yale University
Ph.D. Imperial College London/Cancer Research UK
B.Sc. University of Oxford, UK

Research Description

At its most basic, our work studies how the chemical reactions of biology are organized within the cellular boundaries. Biological organization is both spatial (cellular architecture), and temporal (cellular dynamics). We are interested in how cellular organization is maintained and harnessed by the animal to generate distinct physiological outputs, and how changes in intracellular organization underlie pathophysiological conditions. more

Publications

Calero, M. Whittaker, GR and Collins RN (2001) Yop1p, the yeast homolog of the polyposis locus protein 1, interacts with both Yip1p and Rab proteins and negatively regulates cell growth. J Biol Chem 276: 12100-12.

Calero M, Winand NJ and Collins RN. (2002) Identification of the novel proteins Yip4p and Yip5p as Rab GTPase interacting factors. FEBS Lett. 515: 89-98.

Chen CZ, Calero M, DeRegis CJ, Heidtman M, Barlowe C and Collins RN. (2005) Genetic analysis of yeast Yip1p function reveals a requirement for Golgi-localized rab proteins and rab-Guanine nucleotide dissociation inhibitor. Genetics. 168:1827-41.

Rahl PB, Chen CZ and Collins RN. (2005) Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation. Molecular Cell 17:841-53.

Collins RN. (2005) Application of phylogenetic algorithms to assess Rab functional relationships. Methods Enzymol. 403: 19-28.

Nussbaum M and Collins RN. (2005) Use of search algorithms to define specificity in Rab GTPase domain function. Methods Enzymol. 403: 10-9.

Buvelot Frei S, Rahl PB, Nussbaum M, Briggs BJ, Calero M, Janeczko S, Regan AD, Chen CZ, Barral Y, Whittaker GR, and Collins RN. (2006) Bioinformatic and comparative localization of Rab proteins reveals functional insights into the uncharacterized GTPases Ypt10p and Ypt11p. Mol. Cell. Biol. 26: 7299-317.

Review Articles
Collins RN and Brennwald P. (1999) Rab proteins. In GTPases: Frontiers in Molecular Biology ed. A Hall,, vol. 24, pp137-175, Oxford University Press.
Collins RN. (2003) Rab and ARF GTPase regulation of exocytosis. Mol Membr Biol.:20: 105-15.
Collins RN. (2003) "Getting it on"-- GDI displacement and small GTPase membrane recruitment. Molecular Cell.:12: 1064-6.
Chen CZ and Collins RN. (2005) Insights into biological functions across species: examining the role of Rab proteins in YIP1 family function. Biochem Soc Trans.
Collins RN. (2006) How the ER stays in shape. Cell. 124: 464-6.