Background |
PhD, California Institute of Technology, 1983
BSc, National University of Ireland, 1977
Merck Faculty Development Award
Camille and Henry Dreyfus Teacher-Scholar Award |
Research Description |
The Begley Group is interested in vitamin biosynthetic pathways and mechanistic enzymology, with a focus on the catalysis of complex organic transformations.1 We are currently working on the biosynthesis of NAD, thiamin, pyridoxal phosphate, coenzyme A and vitamin B12. more |
Publications |
Chatterjee, Abhishek; Jurgenson, Christopher T.; Schroeder, Frank C.; Ealick, Steven E.; Begley, Tadhg P. Thiamin Biosynthesis in Eukaryotes: Characterization of the Enzyme-Bound Product of Thiazole Synthase from Saccharomyces cerevisiae and Its Implications in Thiazole Biosynthesis. Journal of the American Chemical Society 2006, 128(22), 7158.
Begley, Tadhg P. Cofactor biosynthesis: an organic chemist's treasure trove. Natural Product Reports 2006, 23(1), 15.
Sun, Guangxing; Fecko, Christopher J.; Nicewonger, Robert B.; Webb, Watt W.; Begley, Tadhg P. DNA-Protein Cross-Linking: Model Systems for Pyrimidine-Aromatic Amino Acid Cross-Linking. Organic Letters 2006, 8(4), 681.
Burns, Kristin E.; Baumgart, Sabine; Dorrestein, Pieter C.; Zhai, Huili; McLafferty, Fred W.; Begley, Tadhg P. Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis. Journal of the American Chemical Society 2005, 127(33), 11602.
Zhang, Yang; Colabroy, Keri L.; Begley, Tadhg P.; Ealick, Steven E. Structural Studies on 3-Hydroxyanthranilate-3,4-dioxygenase: The Catalytic Mechanism of a Complex Oxidation Involved in NAD Biosynthesis. Biochemistry 2005, 44(21), 7632.
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