Jeremy M. Baskin
Assistant Professor
Jeremy Baskin

Phone

607-255-2887

Address

Department of Chemistry & Chemical Biology
Cornell University
461 Weill Hall
Ithaca, NY 14853

Email

Web Sites

Department Profile
Lab Website

Background

Jeremy Baskin is an Assistant Professor and Nancy and Peter Meinig Family Investigator in the Life Sciences in the Department of Chemistry and Chemical Biology and the Weill Institute for Cell and Molecular Biology. A native of Montreal, Canada, Jeremy attended the Massachusetts Institute of Technology, earning a bachelor's degree in Chemistry in 2004. He carried out his graduate studies in Carolyn Bertozzi's laboratory in the Department of Chemistry at UC Berkeley. After receiving his Ph.D. in Chemistry in 2009, Jeremy moved to the Department of Cell Biology at the Yale School of Medicine, where he was a postdoctoral fellow in the laboratory of Pietro De Camilli. Jeremy joined the faculty at Cornell University in August 2015.

Research Description

Research in the Baskin Laboratory centers on pioneering innovative chemical approaches to probe the cell biology of diverse classes of lipids, with a major focus on developing new molecular imaging methods. Lipids are a diverse group of metabolites that function as energy stores, components of membranes, and signaling molecules, and dysregulation of lipid metabolism occurs in many diseases. While lipids have been traditionally studied using in vitro or genetic techniques, chemical biology approaches can enable the rapid and precise interrogation of lipid biology within living systems. The Baskin Laboratory deploys a unique blend of chemical biology, biochemistry, and cell biology approaches to develop innovative methods for imaging and probing various classes of lipids in vivo. Collectively, our studies elucidate mechanisms of fundamental biological processes and also contribute to the understanding of diseases caused by perturbations in lipid metabolism, with a focus on multiple sclerosis and other diseases of the myelin sheath.

Publications

*Baskin JM, *Wu X, Christiano R, Oh MS, Schauder CM, Gazzerro E, Messa M, Baldassari S, Assereto S, Biancheri R, Zara F, Minetti C, Raimondi A, Simons M, Walther TC, Reinisch KM, De Camilli P. "The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane." Nat Cell Biol, 18, 132-38 (2016).

Chung J, Nakatsu F, Baskin JM, De Camilli P. "Plasticity of PI4KIIIα interactions at the plasma membrane." EMBO Rep, 16, 312-20 (2015).

Wu X, Chi RJ, B skin JM, Lucast L, Burd CG, De Camilli P, Reinisch KM. "Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex." Dev Cell, 28, 19-29 (2014).

*Nakatsu F, *Baskin JM, Chung J, Tanner LB, Shui G, Lee SY, Pirruccello M, Hao M, Ingolia NT, Wenk MR, De Camilli P. "PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity." J Cell Biol, 199, 1003-16 (2012).

*Baskin JM, *Dehnert KW, *Laughlin ST, Amacher SL, Bertozzi CR. "Visualizing enveloping layer glycans during zebrafish early embryogenesis."Proc Natl Acad Sci USA, 107, 10360-65 (2010).

Baskin JM and Bertozzi CR. "Copper-free click chemistry: Bioorthogonal reagents for tagging azides." Aldrichimica Acta, 43, 15-23 (2010).

Baskin JM and Bertozzi CR. "Copper-free click chemistry." In Click Chemistry for Biotechnology and Materials Science. Ed. J. Lahann. pp. 25-51, Wiley (2009).

*Laughlin ST, *Baskin JM, Amacher SL, Bertozzi CR. "In vivo imaging of membrane-associated glycans in developing zebrafish. Science, 320, 664-67 (2008). *Equal contribution.

Baskin JM, Prescher JA, Laughlin ST, Agard NJ, Chang PV, Miller IA, Lo A, Codelli JA, Bertozzi CR. "Copper-free click chemistry for dynamic in vivo imaging." Proc Natl Acad Sci USA, 104, 16793-97 (2007).

Baskin JM and Bertozzi CR. "Bioorthogonal click chemistry: Covalent labeling in living systems." QSAR Comb Sci, 26, 1211-19 (2007).

*Agard NJ, *Baskin JM, Prescher JA, Lo A, Bertozzi CR. "A comparative study of bioorthogonal reactions with azides." ACS Chem Biol, 1, 644-48 (2006).