Yimon Aye
Assistant Professor

Yimon Aye

Phone

607-254-4519

Address

Department of Chemistry & Chemical Biology
Cornell University
224A Baker Laboratory
Ithaca, NY 14853

Email

Web Sites

Lab Web Site
Department Profile

Background

Yimon Aye received a B.S. degree in 2003 and a Master’s degree in 2004 in Chemistry from the University of Oxford, and a Ph.D. in Synthetic Methodology from Harvard University in 2009. She became an Assistant Professor in the Department of Chemistry & Chemical Biology at Cornell University in July 2012.

Research Description

The Aye group is working on important biological problems in a multidisciplinary setting in the realms of synthetic organic research chemistry & new reaction discovery, chemical biology, mechanistic biochemistry and mammalian cell biology.

Specific Aims:

1) We are developing a new chemical perturbation technology to deconvolute mammalian redox regulatory matrix in vivo.

2) We are seeking to understand small-molecule-modulated perturbation of protein oligomeric equilibria and how it can be harnessed to control in vivo activities and functions of mammalian regulatory enzymes.

3) We are striving to establish a new chemical platform for directed protein trafficking in mammalian cells.

Selected Publications

Fang, X., Fu, Y., Long, M.J.C., Haegele, J.A., Ge, E.J., Parvez, S., and Aye, Y. (2013) Temporally controlled targeting of 4-hydroxynonenal to specific proteins in living cells. J. Amer. Chem. Soc., accepted for publication ASAP (doi: 10.1021/ja405400k) (http://pubs.acs.org/doi/abs/10.1021/ja405400k) .

Fu, Y., Long, M.J.C., Rigney, M., Parvez, S., Blessing, W.A., and Aye, Y. (2013) Uncoupling of allosteric and oligomeric regulation in a functional hybrid enzyme constructed from Escherichia coli and human ribonucleotide reductase. Biochemistry, accepted for publication (http://pubs.acs.org/doi/abs/10.1021/bi400781z).

Aye, Y., Long, M.J.C., and Stubbe, J. (2012) Mechanistic studies of semicarbazone triapine targeting ribonucleotide reductase in vitro and in mammalian cells: tyrosyl radical quenching not involving reactive oxygen species. J. Biol. Chem. 287, 35768.

Aye, Y., Brignole, E.J., Long, M.J.C., Chitturulu, J., Drennan, C.L., Asturias, F.J., and Stubbe, J. (2012) Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers. Chem. & Biol. 19, 799.

Aye, Y. and Stubbe, J. (2011) Clofarabine 5´-Di and –Triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit. Proc. Natl. Acad. Sci. USA 108, 9815.